KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

G. Hartinger, Christian; A. Jakupec, Michael; Zorbas‐Seifried, Stefanie; Groessl, Michael; Egger, Alexander; Berger, Walter; Zorbas, Haralabos; J. Dyson, Paul; K. Keppler, Bernhard

doi:10.1002/cbdv.200890195

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KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

Published in Chemistry & Biodiversity • Oct 1, 2008

Authors:

Christian G. Hartinger

Michael A. Jakupec

Stefanie Zorbas‐Seifried

Abstract

The promising drug candidate indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) is the second Ru-based anticancer agent to enter clinical trials. In this review, which is an update of a paper from 2006 (Hartinger et al., J. Inorg. Biochem. 2006, 100, 891-904), the experimental evi...

Subject

Chemistry

Indazole

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