Prognostic relevance of the mTOR pathway in renal cell carcinoma

J. Pantuck, Allan; B. Seligson, David; Klatte, Tobias; Yu, Hong‐Jeng; T. Leppert, John; Moore, Laurence; E. O’Toole, Timothy; Gibbons, Jay; S. Belldegrun, Arie; A. Figlin, Robert

doi:10.1002/cncr.22677

Public

Prognostic relevance of the mTOR pathway in renal cell carcinoma

Published in Cancer • Apr 17, 2007

Authors:

Allan J. Pantuck

David B. Seligson

Tobias Klatte

Abstract

BACKGROUND: The mammalian target of rapamycin (mTOR) pathway is up-regulated in many human cancers, and agents targeting the mTOR pathway are in various stages of clinical development. The goal of the study was to evaluate the potential and limitations of targeting the mTOR pathway in renal cell car...

Subject

PTEN

PI3K/AKT/mTOR pathway

Tissue microarray

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