DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 <sup>+</sup> T cells in a spectrum of human MHC I haplotypes

Bozzacco, Leonia; Trumpfheller, Christine; P. Siegal, Frederick; Mehandru, Saurabh; Markowitz, Martin; Carrington, Mary; C. Nussenzweig, Michel; Granelli Piperno, Angela; M. Steinman, Ralph

doi:10.1073/pnas.0610383104

Public

DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 + T cells in a spectrum of human MHC I haplotypes

Published in Proceedings of the National Academy of Sciences • Jan 17, 2007

Authors:

Leonia Bozzacco

Christine Trumpfheller

Frederick P. Siegal

Abstract

Optimal HIV vaccines should elicit CD8+ T cells specific for HIV proteins presented on MHC class I products, because these T cells contribute to host resistance to viruses. We had previously found that the targeting of antigen to dendritic cells (DCs) in mice efficiently induces CD8+ T cell response...

Subject

Cross-presentation

CD8

Cytotoxic T cell

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