VEGF Improves, Whereas sFlt1 Inhibits, BMP2-Induced Bone Formation and Bone Healing Through Modulation of Angiogenesis

Peng, Hairong; Ūsas, Arvydas; Olshanski, Anne; M. Ho, Andrew; Gearhart, Brian; M. Cooper, Gregory; Huard, Johnny

doi:10.1359/jbmr.050708

Public

VEGF Improves, Whereas sFlt1 Inhibits, BMP2-Induced Bone Formation and Bone Healing Through Modulation of Angiogenesis

Published in Journal of Bone and Mineral Research • Nov 1, 2005

Authors:

Hairong Peng

Arvydas Ūsas

Anne Olshanski

Abstract

UNLABELLED: We studied the interaction between VEGF and BMP2 during bone formation and bone healing. Results indicate that VEGF antagonist inhibited BMP2-elicited bone formation, whereas the delivery of exogenous VEGF enhanced BMP2-induced bone formation and bone healing through modulation of angiog...

Subject

Angiogenesis

Bone morphogenetic protein 2

Bone healing

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