Allele-specific copy number analysis of tumors

Van Loo, Peter; Nord, Silje; Christian Lingjærde, Ole; G. Russnes, Hege; Hansine Rye, Inga; Sun, Wei; Weigman, Victor; Marynen, Peter; Zetterberg, Anders; Naume, Bjørn; M. Perou, Charles; Børresen‐Dale, Anne‐Lise; N. Kristensen, Vessela

doi:10.1073/pnas.1009843107

Public

Allele-specific copy number analysis of tumors

Published in Proceedings of the National Academy of Sciences • Sep 13, 2010

Authors:

Peter Van Loo

Silje Nord

Ole Christian Lingjærde

Abstract

We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis of tumors), to accurately dissect the allele-specific copy number of solid tumors, simultaneously estimating and adjusting...

Subject

Loss of heterozygosity

Biology

Allele

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