Cholera toxin B subunit acts as a potent systemic adjuvant for HIV-1 DNA vaccination intramuscularly in mice

Hou, Jue; Liu, Ying; H. Hsi, Jenny; Wang, Hongzhi; Tao, Ran; Shao, Yiming

doi:10.4161/hv.28371

Public

Cholera toxin B subunit acts as a potent systemic adjuvant for HIV-1 DNA vaccination intramuscularly in mice

Published in Human Vaccines & Immunotherapeutics • Mar 14, 2014

Authors:

Jue Hou

Ying Liu

Jenny H. Hsi

Abstract

Cholera toxin B subunit (CTB) was investigated as a classical mucosal adjuvant that can increase vaccine immunogenicity. In this study, we found out the in vitro efficacy of cholera toxin B subunit (CTB) in activating mice bone marrow-derived dendritic cells (BMDCs) through Toll-like receptor signal...

Subject

Immunogenicity

Cholera toxin

Adjuvant

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