CREB-binding Protein/p300 Activates MyoD by Acetylation

Polesskaya, Anna; Duquet, Arnaud; Naguibneva, Irina; Weise, Christoph; Vervisch, Arlette; Bengal, Eyal; Hucho, Ferdinand; Robin, Philippe; Harel‐Bellan, Annick

doi:10.1074/jbc.m003815200

Public

CREB-binding Protein/p300 Activates MyoD by Acetylation

Published in Journal of Biological Chemistry • Nov 1, 2000

Authors:

Anna Polesskaya

Arnaud Duquet

Irina Naguibneva

Abstract

The myogenic protein MyoD requires two nuclear histone acetyltransferases, CREB-binding protein (CBP)/p300 and PCAF, to transactivate muscle promoters. MyoD is acetylated by PCAF in vitro, which seems to increase its affinity for DNA. We here show that MyoD is constitutively acetylated in muscle cel...

Subject

PCAF

MyoD

CREB-binding protein

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