Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR.

PJ, Davis; A, Shih; HY, Lin; LJ, Martino; FB, Davis

doi:10.1074/jbc.m002560200

Public

Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR.

Shared by NobleBlocks on Dec 1, 2000 • 12:00 AM UTC

Authors:

Davis PJ

Shih A

Lin HY

Abstract

Activated nongenomically by l-thyroxine (T(4)), mitogen-activated protein kinase (MAPK) complexed in 10-20 min with endogenous nuclear thyroid hormone receptor (TRbeta1 or TR) in nuclear fractions of 293T cells, resulting in serine phosphorylation of TR. Treatment of cells with the MAPK kinase inhib...

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