Thyroxine Promotes Association of Mitogen-activated Protein Kinase and Nuclear Thyroid Hormone Receptor (TR) and Causes Serine Phosphorylation of TR

J. Davis, Paul; Shih, Ai; Lin, Hung‐Yun; J. Martino, Leon; B. Davis, Faith

doi:10.1074/jbc.m002560200

Public

Thyroxine Promotes Association of Mitogen-activated Protein Kinase and Nuclear Thyroid Hormone Receptor (TR) and Causes Serine Phosphorylation of TR

Published in Journal of Biological Chemistry • Dec 1, 2000

Authors:

Paul J. Davis

Ai Shih

Hung‐Yun Lin

Abstract

Activated nongenomically by l-thyroxine (T(4)), mitogen-activated protein kinase (MAPK) complexed in 10-20 min with endogenous nuclear thyroid hormone receptor (TRbeta1 or TR) in nuclear fractions of 293T cells, resulting in serine phosphorylation of TR. Treatment of cells with the MAPK kinase inhib...

Subject

Thyroid hormone receptor

MAPK/ERK pathway

Phosphorylation

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