A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

Pillai, Sreekumar; Ge, Dongliang; Zhu, Guohua; Kong, Xiangyang; V. Shianna, Kevin; C. Need, Anna; Feng, Sheng; P. Hersh, Craig; Bakke, Per; Gulsvik, Amund; Ruppert, Andreas; C. Lødrup Carlsen, Karin; D. Roses, Allen; J. Anderson, W.; Investigators, ICGN; I. Rennard, Stephen; A. Lomas, David; K. Silverman, Edwin; B. Goldstein, David

doi:10.1371/journal.pgen.1000421

Public

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

Published in PLoS Genetics • Mar 19, 2009

Authors:

Sreekumar Pillai

Dongliang Ge

Guohua Zhu

Abstract

There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of alpha(1)-antitrypsin, which is present in 1-2% of individuals with COPD. We conducted a genome-wide association study...

Subject

Biology

Pulmonary disease

COPD

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