Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

Sebastián, David; Isabel Hernández‐Álvarez, María; Segalés, Jessica; Sorianello, Eleonora; Pablo Muñoz, Juan; Sala, David; Waget, Aurélie; Liesa, Marc; C. Paz, José; Gopalacharyulu, Peddinti; Orešič, Matej; Pich, Sara; Burcelin, Rémy; Palacı́n, Manuel; Zorzano, António

doi:10.1073/pnas.1108220109

Public

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

Published in Proceedings of the National Academy of Sciences • Mar 16, 2012

Authors:

David Sebastián

María Isabel Hernández‐Álvarez

Jessica Segalés

Abstract

Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly coupled to fusion and fission. In this connection, mitofusin 2 (Mfn2) participates in mitochondrial fusion and undergoes repression in muscle f...

Subject

MFN2

Endoplasmic reticulum

mitochondrial fusion

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