The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

P. Siegal, Frederick; Kadowaki, Norimitsu; Shodell, Michael; Fitzgerald‐Bocarsly, Patricia; Shah, Kokila; Ho, Stephen; V. Antonenko, S.; Liu, Yongjun

doi:10.1126/science.284.5421.1835

Public

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

Published in Science • Jun 11, 1999

Authors:

Frederick P. Siegal

Norimitsu Kadowaki

Michael Shodell

Abstract

Interferons (IFNs) are the most important cytokines in antiviral immune responses. "Natural IFN-producing cells" (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, an...

Subject

Immune system

Interferon

Biology

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