Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the <i>CKR5</i> Structural Gene

Dean, Michael; Carrington, Mary; A. Winkler, Cheryl; Huttley, Gavin; W. Smith, Michael; Allikmets, Rando; J. Goedert, James; Buchbinder, Susan; Vittinghoff, Eric; D. Gomperts, Edward; Donfield, Sharyne; Vlahov, David; A. Kaslow, Richard; J. Saah, Alfred; R. Rinaldo, Charles; Detels, Roger; J. O’Brien, Stephen

doi:10.1126/science.273.5283.1856

Public

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

Published in Science • Sep 27, 1996

Authors:

Michael Dean

Mary Carrington

Cheryl A. Winkler

Abstract

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4(+) T lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 structural gene was mapped to human chromosome 3p21, and a 32-base pair deletion allele (CKR5Delta32) was identified that is pre...

Subject

Biology

Allele

Population

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!