Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the
                    <i>CKR5</i>
                    Structural Gene

Dean, Michael; Carrington, Mary; Winkler, Cheryl; A. Huttley, Gavin; W. Smith, Michael; Allikmets, Rando; J. Goedert, James; P. Buchbinder, Susan; Vittinghoff, Eric; Gomperts, Edward; Donfield, Sharyne; Vlahov, David; Kaslow, Richard; Saah, Alfred; Rinaldo, Charles; Detels, Roger; J. O'Brien, Stephen

doi:10.1126/science.273.5283.1856

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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

Shared by NobleBlocks on Sep 27, 1996 • 12:00 AM UTC

Authors:

Michael Dean

Mary Carrington

Cheryl Winkler

Abstract

The chemokine receptor 5 (CKR5) protein serves as a secondary receptor on CD4 + T lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). The CKR5 structural gene was mapped to human chromosome 3p21, and a 32-base pair deletion allele ( CKR5Δ32 ) was identified that is presen...

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