Antagonism of microRNA-126 suppresses the effector function of T
                    <sub>H</sub>
                    2 cells and the development of allergic airways disease

Mattes, Joerg; Collison, Adam; Plank, Maximilian; Phipps, Simon; S. Foster, Paul

doi:10.1073/pnas.0905063106

Public

Antagonism of microRNA-126 suppresses the effector function of T H 2 cells and the development of allergic airways disease

Shared by NobleBlocks on Nov 3, 2009 • 12:00 AM UTC

Authors:

Joerg Mattes

Adam Collison

Maximilian Plank

Abstract

Allergic asthma is an inflammatory disease of the lung characterized by abnormal T helper-2 (T H 2) lymphocyte responses to inhaled antigens. The molecular mechanisms leading to the generation of T H 2 responses remain unclear, although toll-like receptors (TLRs) present on innate immune cells play ...

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