Transcriptional Adaptation of <i>Mycobacterium tuberculosis</i> within Macrophages

Schnappinger, Dirk; Ehrt, Sabine; I. Voskuil, Martin; Liu, Yang; A. Mangan, Joseph; M. Monahan, Irene; Dolganov, Gregory; Efron, Brad; D. Butcher, Philip; Nathan, Carl; K. Schoolnik, Gary

doi:10.1084/jem.20030846

Public

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages

Published in The Journal of Experimental Medicine • Sep 1, 2003

Authors:

Dirk Schnappinger

Sabine Ehrt

Martin I. Voskuil

Abstract

Little is known about the biochemical environment in phagosomes harboring an infectious agent. To assess the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in macrophages from wild-type and nitric oxide (NO) synthase 2-deficient mice before and ...

Subject

Transcriptome

Regulon

Biology

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