ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le <sup>x</sup>

Laurie Phillips, M.; Nudelman, Edward; C Gaeta, F; Perez, Mary; Singhal, Anil; Hakomori, Sen‐itiroh; C. Paulson, James

doi:10.1126/science.1701274

Public

ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le x

Published in Science • Nov 23, 1990

Authors:

M. Laurie Phillips

Edward Nudelman

F C Gaeta

Abstract

Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated endothelial cells of the blood vessel walls. ELAM-1 is a member of the LEC-CAM or selectin family of adhesion molecules that contain a lectin...

Subject

Glycolipid

Sialyl-Lewis X

E-selectin

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