BCL-3 and NF-κB p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages

Wessells, Jennifer; Baer, Mark; A. Young, Howard; Claudio, Estefanı́a; Brown, Keith; Siebenlist, Ulrich; F. Johnson, Peter

doi:10.1074/jbc.m404246200

Public

BCL-3 and NF-κB p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages

Published in Journal of Biological Chemistry • Nov 1, 2004

Authors:

Jennifer Wessells

Mark Baer

Howard A. Young

Abstract

Lipopolysaccharide (LPS) induces expression of tumor necrosis factor alpha (TNFalpha) and other pro-inflammatory cytokines in macrophages. Following its induction, TNFalpha gene transcription is rapidly attenuated, in part due to the accumulation of NF-kappaB p50 homodimers that bind to three kappaB...

Subject

Lipopolysaccharide

P50

NF-κB

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