The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.

Antoniou, John; Steffen, Thomas; R.T. Nelson, Fred; Winterbottom, Neil; Hollander, A.P.; Poole, Robin; Aebi, Max; Alini, M

doi:10.1172/jci118884

Public

The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.

Published in Journal of Clinical Investigation • Aug 15, 1996

Authors:

John Antoniou

Thomas Steffen

Fred R.T. Nelson

Abstract

Very little is known about the turnover of extracellular matrix in the human intervertebral disc. We measured concentrations of specific molecules reflecting matrix synthesis and degradation in predetermined regions of 121 human lumbar intervertebral discs and correlated them with ageing and Thompso...

Subject

Procollagen peptidase

Aggrecan

Extracellular matrix

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!