BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

Reuter, Marcel; N. Zelensky, Alex; Smal, Ihor; Meijering, Erik; A. van Cappellen, Wiggert; Martijn de Gruiter, H.; J. van Belle, Gijsbert; E. van Royen, Martin; B. Houtsmuller, Adriaan; Essers, Jeroen; Kanaar, Roland; Wyman, Claire

doi:10.1083/jcb.201405014

Public

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

Published in The Journal of Cell Biology • Dec 8, 2014

Authors:

Marcel Reuter

Alex N. Zelensky

Ihor Smal

Abstract

Genome maintenance by homologous recombination depends on coordinating many proteins in time and space to assemble at DNA break sites. To understand this process, we followed the mobility of BRCA2, a critical recombination mediator, in live cells at the single-molecule level using both single-partic...

Subject

RAD51

Homologous recombination

DNA

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