Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells.

M, Essler; M, Amano; HJ, Kruse; K, Kaibuchi; PC, Weber; M, Aepfelbacher

doi:10.1074/jbc.273.34.21867

Public

Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells.

Shared by NobleBlocks on Aug 1, 1998 • 12:00 AM UTC

Authors:

Essler M

Amano M

Kruse HJ

Abstract

The role of Rho GTPase and its downstream targets Rho kinase and myosin light chain phosphatase in thrombin-induced endothelial cell contraction was investigated. The specific Rho inactivator C3-transferase from Clostridium botulinum as well as microinjection of the isolated Rho-binding domain of Rh...

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