PI(3,4,5)P <sub>3</sub> and PI(4,5)P <sub>2</sub> Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane

Do Heo, Won; Inoue, Takanari; Sun Park, Wei; Lyang Kim, Man; Ouk Park, Byung; J. Wandless, Thomas; Meyer, Tobias

doi:10.1126/science.1134389

Public

PI(3,4,5)P 3 and PI(4,5)P 2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane

Published in Science • Nov 9, 2006

Authors:

Won Do Heo

Takanari Inoue

Wei Sun Park

Abstract

Many signaling, cytoskeletal, and transport proteins have to be localized to the plasma membrane (PM) in order to carry out their function. We surveyed PM-targeting mechanisms by imaging the subcellular localization of 125 fluorescent protein-conjugated Ras, Rab, Arf, and Rho proteins. Out of 48 pro...

Subject

Phosphatidylinositol

Rab

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