Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4

Peng, Hairong; J. Wright, Vonda; Ūsas, Arvydas; Gearhart, Brian; Shen, Hsain-Chung; H. Cummins, James; Huard, Johnny

doi:10.1172/jci15153

Public

Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4

Published in Journal of Clinical Investigation • Sep 15, 2002

Authors:

Hairong Peng

Vonda J. Wright

Arvydas Ūsas

Abstract

We investigated the interaction between angiogenic and osteogenic factors in bone formation and bone healing with ex vivo gene therapy using muscle-derived stem cells genetically engineered to express human bone morphogenetic protein-4 (BMP4), VEGF, or VEGF-specific antagonist (soluble Flt1). Our re...

Subject

Bone healing

Endochondral ossification

Mesenchymal stem cell

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