The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

Consortium, FANTOM; Suzuki, Harukazu; R R Forrest, Alistair; van Nimwegen, Erik; O Daub, Carsten; J Balwierz, Piotr; M Irvine, Katharine; Lassmann, Timo; Ravasi, Timothy; Hasegawa, Yuki; J L de Hoon, Michiel; Katayama, Shintaro; Schroder, Kate; Carninci, Piero; Tomaru, Yasuhiro; Kanamori-Katayama, Mutsumi; Kubosaki, Atsutaka; Akalin, Altuna; Ando, Yoshinari; Arner, Erik; Asada, Maki; Asahara, Hiroshi; Bailey, Timothy; B Bajic, Vladimir; Bauer, Denis; G Beckhouse, Anthony; Bertin, Nicolas; Björkegren, Johan; Brombacher, Frank; Bulger, Erika; M Chalk, Alistair; Chiba, Joe; Cloonan, Nicole; Dawe, Adam; Dostie, Josee; G Engström, Pär; Essack, Magbubah; J Faulkner, Geoffrey; Lynn Fink, J; Fredman, David; Fujimori, Ko; Furuno, Masaaki; Gojobori, Takashi; Gough, Julian; M Grimmond, Sean; Gustafsson, Mika; Hashimoto, Megumi; Hashimoto, Takehiro; Hatakeyama, Mariko; Heinzel, Susanne

doi:10.1038/ng.375

Public

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

Shared by NobleBlocks on May 1, 2009 • 12:00 AM UTC

Authors:

FANTOM Consortium

Harukazu Suzuki

Alistair R R Forrest

Abstract

Using deep sequencing (deepCAGE), the FANTOM4 study measured the genome-wide dynamics of transcription-start-site usage in the human monocytic cell line THP-1 throughout a time course of growth arrest and differentiation. Modeling the expression dynamics in terms of predicted cis-regulatory sites, w...

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