The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

Suzuki, Harukazu; R. R. Forrest, Alistair; O. Daub, Carsten; Lassmann, Timo; Hasegawa, Yuki; de Hoon, Michiel; Katayama, Shintaro; Carninci, Piero; Tomaru, Yasuhiro; Kanamori-Katayama, Mutsumi; Kubosaki, Atsutaka; Ando, Yoshinari; Arner, Erik; Bertin, Nicolas; Bulger, Erika; Furuno, Masaaki; Hashimoto, Takehiro; Ishihara, Ryoko; Kawaji, Hideya; Kimura, Yasumasa; Kondo, Shinji; Lennartsson, Andreas; Lizio, Marina; Maeda, Norihiro; Nakano, Mika; Okuda-Yabukami, Haruka; Plessy, Charles; Severin, Jessica; Suzuki, Masanori; Suzuki, Takahiro; Waki, Kazunori; Waterhouse, Andrew; Yamaguchi, Kazumi; Yasuda, Jun; Arakawa, Takahiro; Fukuda, Shiro; Imamura, Kengo; Kai, Chikatoshi; Kaiho, Ai; Kawashima, Tsugumi; Kawazu, Chika; Kitazume, Yayoi; Kojima, Miki; Miura, Hisashi; Murakami, Kayoko; Murata, Mitsuyoshi; Ninomiya, Noriko; Nishiyori, Hiromi; Noma, Shohei; Ogawa, Chihiro; Sano, Takuma; Simon, Christophe; Tagami, Michihira; Takahashi, Yukari; Kawai, Jun; Hayashizaki, Y.; G Beckhouse, Anthony; M. Chalk, Alistair; Matigian, Nicholas; A. Wells, Christine; van Nimwegen, Erik; J. Balwierz, Piotr; Pachkov, Mikhail; Zavolan, Mihaela; M. Irvine, Katharine; Schroder, Kate; L. Bailey, Timothy; C. Bauer, Denis; Ravasi, Timothy; Schwartz, Ariel; Tan, Kai; Akalin, Altuna; G. Engström, Pär; Fredman, David; Lenhard, Boris; Asada, Maki; Asahara, Hiroshi; Hashimoto, Megumi; B. Bajić, Vladimir; Dawe, Adam; Essack, Magbubah; Hide, Winston; Hofmann, Oliver; Kaur, Mandeep; Kruger, Adéle; Ross MacPherson, Cameron; A. Maher, Christopher; Maqungo, Monique; Meier, Stuart; Radovanović, Aleksandar; Meier, Stuart; Björkegren, Johan; Tegner, Jesper; Brombacher, Frank; Chiba, Joe; Kimura, Ryuichiro; Nakabayashi, Kazuhiko; Cloonan, Nicole; J. Faulkner, Geoffrey; M. Grimmond, Sean; S. Mattick, John; Simons, Cas; J. Taft, Ryan; Dostie, Josée; Lynn Fink, J.; C. Kerr, Markus; D. Teasdale, Rohan; Fujimori, Ko; Gojobori, Takashi; Ikeo, Kazuho; Konno, T.; Miyamoto, Sei; Okayama, Toshitsugu; Sera, Miho; Gough, Julian; Gustafsson, Mika; Hörnquist, Michael; Hatakeyama, Mariko; Kojima, Toshio; Heinzel, Susanne; Petrovsky, Nikolai; Wu, Linda; Huminiecki, Łukasz; Imamoto, Naoko; Inoue, S; Inoue, Yusuke; Iwayanagi, Takao; Jacobsen, Anders; Krogh, Anders; Lindow, Morten; Nygaard, Sanne; Sandelin, Albin; Valen, Eivind; Winther, Ole; Kimura, Syuhei; Kitano, Hiroaki; Koga, Hisashi; Kumar, Ajit; St. Laurent, George; C. Mar, Jessica; Quackenbush, John; Matsuda, Hideo; Takenaka, Yoichi; Miyamoto‐Sato, Etsuko; Yanagawa, Hiroshi; Nakachi, Yutaka; Okazaki, Yasushi; Orlando, Valerio; Otomo, Jun; Takeda, Shizu; Rehli, Michael; Saito, Rintaro; Schönbach, Christian; A. Semple, Colin; Shirahige, Katsuhiko; J. Sweet, Matthew; S. Taylor, Martin; Teichmann, Sarah; Wahlestedt, Claes; A. Hume, David

doi:10.1038/ng.375

Public

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

Published in Nature Genetics • Apr 19, 2009

Authors:

Harukazu Suzuki

Alistair R. R. Forrest

Carsten O. Daub

Abstract

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differenti...

Subject

Biology

Transcription factor

Gene knockdown

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