Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Siddiquee, Khandaker; Zhang, Shumin; C. Guida, Wayne; A. Blaskovich, Michelle; Greedy, Benjamin; R. Lawrence, Harshani; Richard Yip, M.L.; Jove, Richard; M. McLaughlin, Mark; J. Lawrence, Nicholas; M. Sebti, Saı̈d; Turkson, James

doi:10.1073/pnas.0609757104

Public

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

Published in Proceedings of the National Academy of Sciences • Apr 26, 2007

Authors:

Khandaker Siddiquee

Shumin Zhang

Wayne C. Guida

Abstract

S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray c...

Subject

Virtual screening

Chemistry

Cancer research

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