Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype

Watanabe, Akiko; Toyota, Tomoko; Owada, Yuji; Hayashi, Takeshi; Iwayama, Yoshimi; Matsumata, Miho; Ishitsuka, Yuichi; Nakaya, Akihiro; Maekawa, Motoko; Ohnishi, Tetsuo; Arai, Ryoichi; Sakurai, Katsuyasu; Yamada, Kazuo; Kondo, Hisatake; Hashimoto, Kenji; Osumi, Noriko; Yoshikawa, Takeo

doi:10.1371/journal.pbio.0050297

Public

Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype

Published in PLoS Biology • Nov 6, 2007

Authors:

Akiko Watanabe

Tomoko Toyota

Yuji Owada

Abstract

Deficits in prepulse inhibition (PPI) are a biological marker for schizophrenia. To unravel the mechanisms that control PPI, we performed quantitative trait loci (QTL) analysis on 1,010 F2 mice derived by crossing C57BL/6 (B6) animals that show high PPI with C3H/He (C3) animals that show low PPI. We...

Subject

Prepulse inhibition

Endophenotype

Quantitative trait locus

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