TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

Shibuyà, Hiroshi; Yamaguchi, Toshihiro; Shirakabe, Kyoko; Tonegawa, Akane; Gotoh, Yukiko; Ueno, Naoto; Irie, Kenji; Nishida, Eisuke; Matsumoto, Kunihiro

doi:10.1126/science.272.5265.1179

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TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

Published in Science • May 24, 1996

Authors:

Hiroshi Shibuyà

Toshihiro Yamaguchi

Kyoko Shirakabe

Abstract

Transforming growth factor-beta (TGF-beta) regulates many aspects of cellular function. A member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family, TAK1, was previously identified as a mediator in the signaling pathway of TGF-beta superfamily members. The yeast two-hybrid system ...

Subject

MAP kinase kinase kinase

Signal transduction

Activator (genetics)

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