Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor.

D, Duguay; Sarkissian S, Der; R, Kouz; B, Ongali; R, Couture; D, deBlois

doi:10.1038/sj.bjp.0705642

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Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor.

Shared by NobleBlocks on Jan 26, 2004 • 12:00 AM UTC

Authors:

Duguay D

Der Sarkissian S

Kouz R

Abstract

1. Treatment with enalapril induces smooth muscle cell apoptosis and regression of aortic hypertrophy in spontaneously hypertensive rats (SHRs), whereas combined blockade of angiotensin II AT(1) and AT(2) receptors does not. We postulated that vascular apoptosis with enalapril involves enhanced half...

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