Kinin B2 receptor is not involved in enalapril‐induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor

Duguay, David; Der Sarkissian, Shant; Kouz, Rémi; Ongali, Brice; Couture, Réjean; deBlois, Denis

doi:10.1038/sj.bjp.0705642

Public

Kinin B2 receptor is not involved in enalapril‐induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor

Published in British Journal of Pharmacology • Feb 1, 2004

Authors:

David Duguay

Shant Der Sarkissian

Rémi Kouz

Abstract

1. Treatment with enalapril induces smooth muscle cell apoptosis and regression of aortic hypertrophy in spontaneously hypertensive rats (SHRs), whereas combined blockade of angiotensin II AT(1) and AT(2) receptors does not. We postulated that vascular apoptosis with enalapril involves enhanced half...

Subject

Enalapril

Endocrinology

Internal medicine

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