Gene-Expression Profiles in Hereditary Breast Cancer

Hedenfalk, Ingrid; Duggan, David; Chen, Yidong; D. Radmacher, Michael; Bittner, Michael; H. Simon, Richard; S. Meltzer, Paul; Gusterson, B.A.; Esteller, Manel; Raffeld, Mark; Yakhini, Zohar; Ben-Dor, Amir; Dougherty, Edward; Kononen, Juha; Bubendorf, Lukas; Fehrle, Wilfrid; Pittaluga, Stefania; Gruvberger, Sofia; Loman, Niklas; Johannsson, Oskar; Olsson, Håkan; Wilfond, Benjamin; Sauter, Guido; Kallioniemi, Olli-P.; Borg, Åke; Trent, Jeffrey

doi:10.1056/nejm200102223440801

Public

Gene-Expression Profiles in Hereditary Breast Cancer

Published in New England Journal of Medicine • Feb 22, 2001

Authors:

Ingrid Hedenfalk

David Duggan

Yidong Chen

Abstract

BACKGROUND: Many cases of hereditary breast cancer are due to mutations in either the BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often characteristic of the mutant gene. We hypothesized that the genes expressed by these two types of tumors are also distinctive, perha...

Subject

Breast cancer

Gene

Mutation

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