Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

A. Grossman, Stuart; Ye, Xiaobu; J. Lesser, Glenn; E. Sloan, Andrew; E. Carraway, Hetty; Desideri, Serena; Piantadosi, Steven

doi:10.1158/1078-0432.ccr-11-0774

Public

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

Published in Clinical Cancer Research • Jul 8, 2011

Authors:

Stuart A. Grossman

Xiaobu Ye

Glenn J. Lesser

Abstract

PURPOSE: Patients with high-grade gliomas (HGG) routinely receive radiation, temozolomide, and glucocorticoids. As each of these is immunosuppressive, we conducted a prospective, multicenter study to follow CD4 counts over time and determine whether low CD4 counts were associated with adverse outcom...

Subject

Temozolomide

Medicine

Immunosuppression

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