Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

M. Shaw, Leslie; Vanderstichele, Hugo; Knapik-Czajka, Małgorzata; M. Clark, Christopher; Aisen, Paul; C. Petersen, Ronald; Blennow, Kaj; Soares, Holly; J. Simon, Adam; Lewczuk, Piotr; A. Dean, Robert; Siemers, Eric; Z. Potter, William; M.‐Y. Lee, Virginia; Q. Trojanowski, John; Disease Neuroimaging Initiative, Alzheimer's

doi:10.1002/ana.21610

Public

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

Published in Annals of Neurology • Mar 19, 2009

Authors:

Leslie M. Shaw

Hugo Vanderstichele

Małgorzata Knapik-Czajka

Abstract

OBJECTIVE: Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects. METHODS: Amyloid-beta 1 to 42 peptide (A beta(1-42)), total tau (t-tau), and tau phosphorylated at the threonine 181 were measured in (1) cer...

Subject

Biomarker

Cerebrospinal fluid

Cohort

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