A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*

E. Nestler, John; P. POWERS, LINDA; W. Matt, Dennis; A. Steingold, Kenneth; R. Plymate, Stephen; S. Rittmaster, Roger; N. Clore, John; G. Blackard, William

doi:10.1210/jcem-72-1-83

Public

A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*

Published in The Journal of Clinical Endocrinology & Metabolism • Jan 1, 1991

Authors:

John E. Nestler

LINDA P. POWERS

Dennis W. Matt

Abstract

To determine whether hyperinsulinemia can directly reduce serum sex hormone-binding globulin (SHBG) levels in obese women with the polycystic ovary syndrome, six obese women with this disorder were studied. Before study, ovarian steroid production was suppressed in each woman by the administration o...

Subject

Endocrinology

Internal medicine

Hyperinsulinemia

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