Changes in Mitochondrial DNA as a Marker of Nucleoside Toxicity in HIV-Infected Patients

C. F. Côté, Hélène; L. Brumme, Zabrina; J.P. Craib, Kevin; S. Alexander, Christopher; Wynhoven, Brian; Ting, Lillian; Wong, Hubert; Harris, Marianne; Richard Harrigan, P.; V. O’Shaughnessy, Michael; Montaner, Julio

doi:10.1056/nejmoa012035

Public

Changes in Mitochondrial DNA as a Marker of Nucleoside Toxicity in HIV-Infected Patients

Published in New England Journal of Medicine • Mar 14, 2002

Authors:

Hélène C. F. Côté

Zabrina L. Brumme

Kevin J.P. Craib

Abstract

BACKGROUND: Nucleoside analogues can induce toxic effects on mitochondria by inhibiting the human DNA polymerase gamma. The toxic effects can range from increased serum lactate levels to potentially fatal lactic acidosis. We studied changes in mitochondrial DNA relative to nuclear DNA in the periphe...

Subject

Hyperlactatemia

Mitochondrial toxicity

Mitochondrial DNA

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