The Transcription Factor Mrr1p Controls Expression of the MDR1 Efflux Pump and Mediates Multidrug Resistance in Candida albicans

Morschhäuser, Joachim; S. Barker, Katherine; T. Liu, Teresa; Blaß-Warmuth, Julia; Homayouni, Ramin; David Rogers, P.

doi:10.1371/journal.ppat.0030164

Public

The Transcription Factor Mrr1p Controls Expression of the MDR1 Efflux Pump and Mediates Multidrug Resistance in Candida albicans

Published in PLoS Pathogens • Oct 29, 2007

Authors:

Joachim Morschhäuser

Katherine S. Barker

Teresa T. Liu

Abstract

Constitutive overexpression of the MDR1 (multidrug resistance) gene, which encodes a multidrug efflux pump of the major facilitator superfamily, is a frequent cause of resistance to fluconazole and other toxic compounds in clinical Candida albicans strains, but the mechanism of MDR1 upregulation has...

Subject

Efflux

Candida albicans

Multiple drug resistance

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