The Prevention and Treatment of Missing Data in Clinical Trials

J. A. Little, Roderick; B. D’Agostino, Ralph; L. Cohen, Michael; Dickersin, Kay; S. Emerson, Scott; T. Farrar, John; Frangakis, Constantine; W. Hogan, Joseph; Molenberghs, Geert; A. Murphy, Susan; D. Neaton, James; Rotnitzky, Andrea; O. Scharfstein, Daniel; Joe Shih, Weichung; P. Siegel, Jay; S. Stern, Hal

doi:10.1056/nejmsr1203730

Public

The Prevention and Treatment of Missing Data in Clinical Trials

Published in New England Journal of Medicine • Oct 3, 2012

Authors:

Roderick J. A. Little

Ralph B. D’Agostino

Michael L. Cohen

Abstract

Missing data in clinical trials can have a major effect on the validity of the inferences that can be drawn from the trial. This article reviews methods for preventing missing data and, failing that, dealing with data that are missing.

Subject

Medicine

Missing data

Clinical trial

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