An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Rock, Fernando; Mao, Weimin; Yaremchuk, A.; A. Tukalo, M.; Crépin, Thibaut; Zhou, Huchen; Zhang, Yong-Kang; Hernandez, Vincent; Akama, Tsutomu; J. Baker, Stephen; J. Plattner, Jacob; Shapiro, Lucy; A. Martinis, Susan; J. Benkovic, Stephen; Cusack, S.; Alley, M.R.

doi:10.1126/science.1142189

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An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Published in Science • Jun 21, 2007

Authors:

Fernando Rock

Weimin Mao

A. Yaremchuk

Abstract

Aminoacyl-transfer RNA (tRNA) synthetases, which catalyze the attachment of the correct amino acid to its corresponding tRNA during translation of the genetic code, are proven antimicrobial drug targets. We show that the broad-spectrum antifungal 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2...

Subject

Transfer RNA

Aminoacyl tRNA synthetase

Genetic code

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