Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

A. Aaltonen, Lauri; Salovaara, Reijo; Kristo, Paula; Canzian, Federico; Hemminki, Akseli; Peltomäki, Païvi; B. Chadwick, Robert; Kääriäinen, Helena; Eskelinen, Matti; Järvinen, Heikki; Mecklin, Jukka‐Pekka; de la Chapelle, Albert; Percesepe, Antonio; Ahtola, Heikki; Härkönen, N; Julkunen, Risto; Kangas, Eero; Ojala, Seppo; Tulikoura, Jukka; Valkamo, Erkki

doi:10.1056/nejm199805213382101

Public

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

Published in New England Journal of Medicine • May 21, 1998

Authors:

Lauri A. Aaltonen

Reijo Salovaara

Paula Kristo

Abstract

BACKGROUND: Genetic disorders that predispose people to colorectal cancer include the polyposis syndromes and hereditary nonpolyposis colorectal cancer. In contrast to the polyposis syndromes, hereditary nonpolyposis colorectal cancer lacks distinctive clinical features. However, a germ-line mutatio...

Subject

Medicine

Colorectal cancer

MLH1

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