QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

P. Heyes, Melvyn; Saito, Kuniaki; S. Crowley, Jeffrey; E. Davis, Lara; A. Demitrack, Mark; G. Der, Margaret; A. Dilling, Louise; Elia, Josephine; J.P. Kruesi, Markus; A. Lackner, Andrew; A. LARSEN, S.; Lee, K.; L. Leonard, Henrietta; P. Markey, Sanford; Martín, A; Milstein, Stuart; Maral Mouradian, M.; R. Pranzatelli, Michael; J. Quearry, Bonnie; Μ. Salazar, Andres; E. Smith, Michael; Strauss, Sylvia; Sunderland, Trey; W. SWEDO, S.; W. Tourtellotte, W.

doi:10.1093/brain/115.5.1249

Public

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

Published in Brain • Jan 1, 1992

Authors:

Melvyn P. Heyes

Kuniaki Saito

Jeffrey S. Crowley

Abstract

Neurological dysfunction, seizures and brain atrophy occur in a broad spectrum of acute and chronic neurological diseases. In certain instances, over-stimulation of N-methyl-D-aspartate receptors has been implicated. Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synth...

Subject

Quinolinic acid

Kynurenic acid

Kynurenine

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