Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

Lal, Himal; L. Cunningham, Anthony; Godeaux, Olivier; Chlíbek, Roman; Díez‐Domingo, Javier; Hwang, Shinn‐Jang; J. Levin, Myron; E. McElhaney, Janet; Põder, Airi; Puig‐Barberà, Joan; Vesikari, Timo; Watanabe, Daisuke; Yin Weckx, Lily; Zahaf, Toufik; C. Heineman, Thomas

doi:10.1056/nejmoa1501184

Public

Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

Published in New England Journal of Medicine • Apr 28, 2015

Authors:

Himal Lal

Anthony L. Cunningham

Olivier Godeaux

Abstract

BACKGROUND: In previous phase 1-2 clinical trials involving older adults, a subunit vaccine containing varicella-zoster virus glycoprotein E and the AS01B adjuvant system (called HZ/su) had a clinically acceptable safety profile and elicited a robust immune response. METHODS: We conducted a randomiz...

Subject

Medicine

Placebo

Vaccination

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