Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

L. Semenza, Gregg; Jiang, Bing‐Hua; W. Leung, Sandra; Passantino, Rosa; Concordet, Jean‐Paul; Maire, Pascal; Giallongo, Agata

doi:10.1074/jbc.271.51.32529

Public

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

Published in Journal of Biological Chemistry • Dec 1, 1996

Authors:

Gregg L. Semenza

Bing‐Hua Jiang

Sandra W. Leung

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor, and other proteins that are important for maint...

Subject

Promoter

Lactate dehydrogenase A

Transcription factor

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