The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPK Pathways

Gao, Dan; Nong, Shanwei; Huang, Xiuqing; Lu, Yonggang; Zhao, Hong‐Ye; Lin, Yajun; Man, Yong; Wang, Shu; Yang, Jiefu; Li, Jian

doi:10.1074/jbc.m110.128694

Public

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPK Pathways

Published in Journal of Biological Chemistry • Jul 21, 2010

Authors:

Dan Gao

Shanwei Nong

Xiuqing Huang

Abstract

Elevated plasma free fatty acid (FFA) levels in obesity may play a pathogenic role in the development of insulin resistance. However, molecular mechanisms linking FFA to insulin resistance remain poorly understood. Oxidative stress acts as a link between FFA and hepatic insulin resistance. NADPH oxi...

Subject

NADPH oxidase

Insulin resistance

Internal medicine

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