Transcriptional Regulation of Nanog by OCT4 and SOX2

J. Rodda, David; Chew, Joon-Lin; Lim, Leng-Hiong; Loh, Yuin‐Han; Wang, Bei; Ng, Huck‐Hui; Robson, Paul

doi:10.1074/jbc.m502573200

Public

Transcriptional Regulation of Nanog by OCT4 and SOX2

Published in Journal of Biological Chemistry • Apr 29, 2005

Authors:

David J. Rodda

Joon-Lin Chew

Leng-Hiong Lim

Abstract

Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oc...

Subject

Homeobox protein NANOG

SOX2

Induced pluripotent stem cell

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