Tritiated Imipramine Binding Sites Are Decreased in Platelets of Untreated Depressed Patients

The high-affinity binding of triatiated imipramine to platelet membranes was compared in samples from 16 untreated depressed women and 21 age-matched controls of the same sex. The maximal binding in the depressed group was significantly lower than that of the controls, although the affinity constant... View More