A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab.

Aim Omalizumab, a humanized IgG monoclonal antibody that binds to human immunoglobulin E (IgE), interrupts the allergic cascade in asthmatic patients. The aim was to compare simultaneously drug exposure and IgE biomarker responses in Japanese and White patient populations.Methods An instantaneous eq... View More