Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Gao, Zhan‐Guo; Hwang, Daniel; Bataille, Fredly; Lefevre, Michael; A. York, David; J. Quon, Michael; Ye, Jianping

doi:10.1074/jbc.m209459200

Public

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Published in Journal of Biological Chemistry • Dec 1, 2002

Authors:

Zhan‐Guo Gao

Daniel Hwang

Fredly Bataille

Abstract

Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus. One mechanism mediating insulin resistance may involve the phosphorylation of serine residues in insulin receptor substrate-1 (IRS-1), leading to impairment in the ability of IRS-1 to activate downstream p...

Subject

Insulin receptor

Insulin receptor substrate

Phosphorylation

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