<i>IDH1</i> and <i>IDH2</i> mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

Fernanda Amary, Maria; Bácsi, Krisztián; Maggiani, Francesca; Damato, Stephen; Halai, Dina; Berisha, Fitim; Pollock, Robin; O’Donnell, Paul; Grigoriadis, Anita; C. Diss, Tim; Eskandarpour, Malihe; Presneau, Nadège; C.W. Hogendoorn, Pancras; Andrew Futreal, P.; Tirabosco, Roberto; M. Flanagan, Adrienne

doi:10.1002/path.2913

Public

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

Published in The Journal of Pathology • Apr 7, 2011

Authors:

Maria Fernanda Amary

Krisztián Bácsi

Francesca Maggiani

Abstract

Somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in gliomas and acute myeloid leukaemia (AML). Since patients with multiple enchondromas have occasionally been reported to have these conditions, we hypothesized that the same mutations would occur in cartilaginous neoplasms. Appr...

Subject

IDH2

Isocitrate dehydrogenase

Chondrosarcoma

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