Involvement of endogenous opioid peptides and nitric oxide in the blunted chronotropic and inotropic responses to β‐adrenergic stimulation in cirrhotic rats

Ebrahimi, Farzad; Tavakoli, Sina; Reza Hajrasouliha, Amir; Sadeghipour, Hamed; Dehghani, Mehdi; Hossein Ahmadi, Seyed; Reza Dehpour, Ahmad

doi:10.1111/j.1472-8206.2006.00431.x

Public

Involvement of endogenous opioid peptides and nitric oxide in the blunted chronotropic and inotropic responses to β‐adrenergic stimulation in cirrhotic rats

Published in Fundamental and Clinical Pharmacology • Jul 24, 2006

Authors:

Farzad Ebrahimi

Sina Tavakoli

Amir Reza Hajrasouliha

Abstract

It is well known that chronotropic and inotropic responses to beta-adrenergic stimulation are impaired in cirrhosis, but the exact reason is not clear. Considering the inhibitory effect of endogenous opioid peptides and nitric oxide (NO) on beta-adrenergic pathway, we examined their roles in hypores...

Subject

Chronotropic

Internal medicine

Endocrinology

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