Optimized gene editing technology for <i>Drosophila melanogaster</i> using germ line-specific Cas9

Ren, Xingjie; Sun, Jin; E. Housden, Benjamin; Hu, Yanhui; Roesel, Charles; Lin, Shuailiang; Liu, Luping; Yang, Zhihao; Mao, Decai; Sun, Lingzhu; Wu, Qujie; Ji, Jun‐Yuan; Xi, Jianzhong; E. Mohr, Stephanie; Jiang, Xu; Perrimon, Norbert; Ni, Jian‐Quan

doi:10.1073/pnas.1318481110

Public

Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9

Published in Proceedings of the National Academy of Sciences • Nov 4, 2013

Authors:

Xingjie Ren

Jin Sun

Benjamin E. Housden

Abstract

The ability to engineer genomes in a specific, systematic, and cost-effective way is critical for functional genomic studies. Recent advances using the CRISPR-associated single-guide RNA system (Cas9/sgRNA) illustrate the potential of this simple system for genome engineering in a number of organism...

Subject

Genome editing

CRISPR

Cas9

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