Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging

Yang, Lily; Mao, Hui; Andrew Wang, Y.; Cao, Zehong; Peng, Xianghong; Wang, Xiaoxia; Duan, Hongwei; Ni, Chunchun; Yuan, Qing‐An; P. Adams, Gregory; Smith, Mark; C. Wood, William; Gao, Xiaohu; Nie, Shuming

doi:10.1002/smll.200800714

Public

Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging

Published in Small • Dec 18, 2008

Authors:

Lily Yang

Hui Mao

Y. Andrew Wang

Abstract

Epidermal growth factor receptor (EGFR) targeted nanoparticle are developed by conjugating a single-chain anti-EGFR antibody (ScFvEGFR) to surface functionalized quantum dots (QDs) or magnetic iron oxide (IO) nanoparticles. The results show that ScFvEGFR can be successfully conjugated to the nanopar...

Subject

In vivo

Internalization

Epidermal growth factor receptor

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