Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction

Prasad, Manoj; Kaur, Jasmeet; J. Pawlak, Kevin; Bose, Mahuya; M. Whittal, Randy; S. Bose, Himangshu

doi:10.1074/jbc.m114.605808

Public

Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Regulates Steroidogenic Activity via Steroidogenic Acute Regulatory Protein (StAR)-Voltage-dependent Anion Channel 2 (VDAC2) Interaction

Published in Journal of Biological Chemistry • Dec 11, 2014

Authors:

Manoj Prasad

Jasmeet Kaur

Kevin J. Pawlak

Abstract

Steroid hormones are essential for carbohydrate metabolism, stress management, and reproduction and are synthesized from cholesterol in mitochondria of adrenal glands and gonads/ovaries. In acute stress or hormonal stimulation, steroidogenic acute regulatory protein (StAR) transports substrate chole...

Subject

Steroidogenic acute regulatory protein

Endoplasmic reticulum

Voltage-dependent anion channel

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