<i>Mycobacterium tuberculosis</i> secretory proteins CFP‐10, ESAT‐6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide‐induced NF‐κB transactivation by downregulation of reactive oxidative species (ROS) production

Ganguly, Niladri; Huong Giang, Pham; Gupta, Chitra; K. Basu, Sandip; Siddiqui, Imran; M. Salunke, Dinakar; Sharma, Pawan

doi:10.1038/sj.icb.7100117

Public

Mycobacterium tuberculosis secretory proteins CFP‐10, ESAT‐6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide‐induced NF‐κB transactivation by downregulation of reactive oxidative species (ROS) production

Published in Immunology and Cell Biology • Oct 2, 2007

Authors:

Niladri Ganguly

Pham Huong Giang

Chitra Gupta

Abstract

Mycobacterium tuberculosis (Mtb) causes death of 2-3 million people annually and is considered one of the most successful intracellular pathogens to persist inside the host macrophage. Recent studies have implicated the role of RD-1 region of Mtb genome in the mycobacterial pathogenesis. The role of...

Subject

Transactivation

Downregulation and upregulation

Reactive oxygen species

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