Mycobacterium tuberculosis secretory proteins CFP-10, ESAT-6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide-induced NF-kappaB transactivation by downregulation of reactive oxidative species (ROS) production.

N, Ganguly; PH, Giang; C, Gupta; SK, Basu; I, Siddiqui; DM, Salunke; P, Sharma

doi:10.1038/sj.icb.7100117

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Mycobacterium tuberculosis secretory proteins CFP-10, ESAT-6 and the CFP10:ESAT6 complex inhibit lipopolysaccharide-induced NF-kappaB transactivation by downregulation of reactive oxidative species (ROS) production.

Shared by NobleBlocks on Oct 2, 2007 • 12:00 AM UTC

Authors:

Ganguly N

Giang PH

Gupta C

Abstract

Mycobacterium tuberculosis (Mtb) causes death of 2-3 million people annually and is considered one of the most successful intracellular pathogens to persist inside the host macrophage. Recent studies have implicated the role of RD-1 region of Mtb genome in the mycobacterial pathogenesis. The role of...

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