Cortistatins A, B, C, and D, Anti-angiogenic Steroidal Alkaloids, from the Marine Sponge <i>Corticium simplex</i>

Aoki, Shunji; Watanabe, Yasuo; Sanagawa, Mami; Setiawan, Andi; Kotoku, Naoyuki; Kobayashi, Motomasa

doi:10.1021/ja057404h

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Cortistatins A, B, C, and D, Anti-angiogenic Steroidal Alkaloids, from the Marine Sponge Corticium simplex

Published in Journal of the American Chemical Society • Feb 17, 2006

Authors:

Shunji Aoki

Yasuo Watanabe

Mami Sanagawa

Abstract

Four novel steroidal alkaloids named cortistatins A (1), B (2), C (3), and D (4) consisting of a 9(10-19)-abeo-androstane and isoquinoline skeleton have been isolated from the marine sponge Corticium simplex. The absolute stereostructures of 1-4 were elucidated by detailed 2D NMR, CD, and X-ray crys...

Subject

Chemistry

Sponge

Umbilical vein

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